Built on Science, not Shortcuts.
Japanese Longevity Research to Help Skin Perform at Its Best.
25+ years of longevity science research. Japan's approach to aging skin—now available in the US.
SCIENCE-FIRST SKINCARE
The Research Foundation
Thinking differently has been a core of Otsuka since the company’s beginning nearly a century ago, when Busaburo Otsuka formed a company (Otsuka Seiyaku Kogyo-bu). Since 1921, Otsuka has expanded to nearly 174 factories and 46 research institutes around the world.
Where Japanese skin science approaches Visible Skin aging differently:
THE INNERSIGNAL DIFFERENCE
An Ingredient the Skincare Industry Has Never Seen.
Energy Signal AMP (INCI: Disodium Adenosine Phosphate) is a naturally occurring nucleotide to support skin's energy and the natural renewal cycle - promoting rejuvenation and a brighter, healthier complexion.
THE BIOLOGICAL PROBLEM
Aging Skin Isn’t Damaged Skin. It’s Low-Energy Skin.
Over time, skin loses the energy it needs to stay even and luminous. Not because it’s broken — because it’s running low.
Energy Signal AMP
Exosome
Retinol
Vitamin-C
Otsuka Otsu Research Laboratories · Proprietary Ingredient
Energy Signal AMP
Absorbs fast and easily
Helps shed unwanted dead skin cells
Helps realign skin's natural vitality
Replenish skin's moisture barrier
*4-week result of Rejuvenate Extract, N=29, 2025
*4-week result of Rejuvenate Extract, N=29, 2025
The Clinical Record
Visible Proof. Real Skin. Real Change.
Your skin has a signal. We amplify it.
3X¹
Increase in hydration.
29%²
Visible wrinkle reduction.
9%³
Reduction in visible age spots.
1. 24 weeks, N=10, 2000 | 2. 24 weeks, N=10, 2000 | 3. 8 weeks, N=8, 2008
Questions, Answered.
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Powered by Energy Signal AMP
One Signal.
Lasting Change.
The longevity science you've been waiting for. Pharmaceutical-grade. Fragrance-free. The result of 25+ years asking better questions.
