Frequently Asked Questions

When you order the 14-Day Trial Kit, your 28 sachets ship immediately — you pay shipping only. 14 days after your kit is delivered, your first full-size Rejuvenate Extract ships at $79. That starts your monthly subscription. Your charge date is in your confirmation email and account dashboard from day one.

You are charged $79 on the day your first full-size ships — 14 days after your trial kit is delivered. After that, every 30 days on your subscription renewal date. Your charge dates are always visible in your account dashboard.

Log in to your account and click Cancel Subscription. Your subscription stops immediately. There is no minimum commitment.

Cancel any time before Day 14 from your account. If you cancel before the 14-day mark, your full-size Rejuvenate Extract will not ship and you will not be charged $79. You only pay the shipping fee for the trial kit.

Research suggests that AMP-related processes are involved in maintaining healthy, natural skin renewal cycle. As skin ages, these natural processes can become less active.

Vitamin C and retinol primarily focus on "correcting" visible signs of aging, such as uneven tone, fine lines, and wrinkles. While highly effective, some forms of Vitamin C and retinol can cause irritation, dryness, or sensitivity for certain skin types. AMP takes a different approach by supporting the skin's natural renewal cycle, helping promote radiance, smoothness, firmness, and overall skin longevity without relying on aggressive exfoliation or turnover acceleration.

Otsuka Pharmaceutical is a global healthcare company founded in Japan. For decades, Otsuka has developed pharmaceutical products, nutraceuticals, and consumer health innovations guided by a commitment to improving people's health and well-being. Applying the same scientific rigor and research-driven approach, Otsuka has also brought innovation to skincare—leading to the development of InnerSignal.

28 individually sealed single-dose sachets -- one morning application and one evening application for 14 consecutive days.

Yes. The formula in the trial sachets is identical to the full-size Rejuvenate Extract. Same AMP. Same ingredients. The sachet is a packaging format, not a reduced version of the product.

Each sachet is sealed at manufacturing to protect the formula from air and light, which degrade active ingredients over time. Every application is as fresh as the first. This is a pharmaceutical packaging standard.

After cleansing, apply three pumps to five points – cheeks, forehead, nose and chin. Gently spread over the entire face. Use morning and evening as part of your daily skincare routine.

Yes. InnerSignal can be incorporated into most skincare routines and layered with moisturizers, sunscreen, and other skincare products. For daytime use, we recommend applying a broad-spectrum SPF after InnerSignal Rejuvenate Extract to help protect your skin from UV damage.

Individual results vary. Many users begin noticing improvements in hydration and skin appearance within the first few weeks, with continued visible benefits over time with consistent use.

Continue your normal morning and evening schedule. Do not double-dose. Missing one application does not reset the protocol.

The Rejuvenate Extract is formulated without added fragrance. If you have a known sensitivity to specific ingredients, review the full INCI list on the product page before use. We recommend patch testing any new skincare product before full-face application. 

Yes. The Rejuvenate Extract contains no added fragrance. 

For the full-size Rejuvenate Extract, recommend using within 12-months of first opening.

Please consult your doctor before using any new skincare product during pregnancy or while breastfeeding.

Orders are typically processed and shipped within 1–2 business days. Delivery times vary depending on your location. Once your order ships, you'll receive a confirmation email with tracking information so you can follow its journey to your doorstep.

We offer free U.S. shipping on every subscription delivery. The 14-Day Trial Kit is subject to a separate shipping fee.