OTSUKA PHARMACEUTICAL CO., LTD.
25+ years of Research. One Answer.
Otsuka Pharmaceutical, Co., Ltd. founded Research Institute in search of a way to boost skin biology for youthful, healthy skin.
Who We Are
Most skincare relies on ingredients that smooth the skin's surface. More than 25 years ago, Otsuka began researching a different question: What are the biological foundations of youthful-looking skin?
DISCOVERY
the breakthrough molecule that energizes everything.
AMP is a cellular energy compound your skin already produces — and increasingly stops producing with age.
Otsuka's researchers discovered that when the basal layer has adequate cellular energy, it manages melanin accumulation naturally. The way younger skin does.
Real Results
Energy Signal AMP is clinically proven to support your skin's longevity
3X¹
Increase in hydration.
29%²
Visible wrinkle reduction.
9%³
Reduction of visible age spots.
1. 24 weeks, N=10, 2000 | 2. 24 weeks, N=10, 2000 | 3. 8 weeks, N=8, 2008
3X¹
Increase in hydration.
29%²
Visible wrinkle reduction.
9%³
Reduction of visible age spots.
Trusted by Thousands
Origin Timeline
The Journey Behind the Formula
1921
Busaburo Otsuka founded Otsuka in Tokushima Prefecture, Japan, with an unconventional idea and the belief that anything is possible. Otsuka has been on a journey of creativity and innovation ever since.
1985
The first Otsuka US research and development base was established in Rockville, Maryland. Just a few years later, in 1989, Otsuka’s first US commercial organization was created, Otsuka America Pharmaceutical, Inc (OAPI).
2026
Today, the Otsuka Holdings Co, Ltd, that has over 180 companies, with more than 45,000 employees in 28 countries around the world.
SKINCARE THAT THINKS LONGTERM
Hypoallergenic
Fragrance-Free
Mineral oil free
Hypoallergenic
Thoughtfully formulated to minimise the risk of irritation, so even sensitive skin can experience the full benefits of Energy Signal AMP.
Fragrance-Free
Contains no added fragrance, so every application stays focused on what matters: visibly healthier, renewed skin.
Mineral oil free
The formula absorbs cleanly and works in harmony with the skin's own renewal process.
Thoughtfully formulated to minimise the risk of irritation, so even sensitive skin can experience the full benefits of Energy Signal AMP.
Contains no added fragrance, so every application stays focused on what matters: visibly healthier, renewed skin.
The formula absorbs cleanly and works in harmony with the skin's own renewal process.
Explore the Science Behind AMP
Explore the Science Behind AMP
Experience the 14-Day Trial
Experience the 14-Day Trial
Your Source for Smarter Skincare
Your Source for Smarter Skincare
Questions? We love to chat! Contact Us
Questions, Answered.
Everything you need to know before you get started.
