NEW! Rejuvenate Extract
JAPANESE SCIENCE You Can See.
20+ years of research, now in one bottle. Experience visibly brighter, healthier, more hydrated skin in just one step.
InnerSignal Rejuvenate Extract
Fast-absorbing milky serum
30ml, 1.01 fl oz
Japan’s breakthrough approach to skin longevity is clinically proven to help visibly reduce the appearance of age spots, wrinkle and fine lines, and deliver deep hydration.
Powered by Japanese research and breakthrough ingredient technology, this science-backed serum targets visible signs of aging and supports long-term skin health and longevity.
- CyclesMoisturizes
- WrinklesSmoothes
- Brightens
- Hydrates
25% OFF
Award-winning
Japanese Hero Serum.
Hear What People Are Saying
“I've worked in beauty for over 17 years. And this is the serum I'm using right now”
“This one serum has taken the place of three separate steps in my skincare routine”
“Good skin care isn't about doing more. It's about choosing products that work for me”
“My routine feels way less complicated and way more intentional”
Clinical Proof
Rejuvenate Extract has been clinically shown to visibly improve multiple signs of aging.
*Objective third-party clinical evaluation using Visia® imaging reveals measurable results of consistent use.
Before
AfterVisible skin texture & tone
Before
AfterVisible wrinkle counts
Before
AfterVisibly pore countsVisible Results
100%1
Wrinkles improved
100%2
Softer + Hydrated
95%3
Brighter + Radiant
91%4
Mid-face Looked Lifted
3X5
Hydration Increase
82.6%6
Visible improvement of Age Spots
1-4. N=22, 2025 | 5. 24 weeks, N=10, 2000 | 6. 12 weeks, N=23, 2025
1-4. N=22, 2025 | 5. 24 weeks, N=10, 2000
6. 12 weeks, N=23, 2025
Real skin. Real results.
See what people are saying after adding InnerSignal to their routine.
Before
After*
Before
After*
Before
After**Results after continued use of InnerSignal Rejuvenate Extract. Results may vary by individual.
In the news
Trusted in Japan for more than 2 decades.
BITEKI
Japan
My Most-Loved, Super-Repeat Item
Yuka, Beauty Editor
MAQUIA
Japan
Best in Brightening CatTrusted Products For The Appearance of Dark Spots
VoCE
Japan
Best in Brightening Category #2 🏆
POWERED BY ENERGY SIGNAL AMP
Our Hero Ingredient. How it works
DELIVERS THE SIGNAL
Energy Signal AMP in fine emulsion particles, for efficient delivery into skin.
SUPPORTS SKIN RENEWAL
AMP is a natural molecule that fuels skin’s renewal cycle.
SUPPORTS NATURAL TURNOVER
Helps skin naturally shed older cells and built-up melanin.
FRESHER-LOOKING SKIN
Clearer, smoother, more even-looking skin that feels hydrated and firm.
BORN IN LAKE BIWA.20+ YEARS OF RESEARCH.Results you can trust.
InnerSignal was born from a long tradition of Japanese scientific innovation—bringing together Otsuka Pharmaceutical’s research heritage and more than two decades of dedicated skin science.
The main goal: to make healthy, youthful skin a long-term reality.
100+ YEARS
of scientific
innovation20+ YEARS
of InnerSignal research
and developmentBREAKTHROUGH
Japanese breakthrough
innovationENERGY SIGNAL AMP
Proprietary technology
developed through Japanese research
Ready to Experience Japanese Skin Longevity?
Get my free 14 day trial
Questions,Answered.
Everything you need to know before you get started.
InnerSignal is a Japanese skincare brand developed by Otsuka Pharmaceutical Co., Ltd., designed to support healthy, youthful looking skin through science-backed skincare innovation.
InnerSignal focuses on skin health as the foundation of lasting beauty. Rather than targeting a single concern, the serum is designed to support multiple visible signs of skin aging, including dryness, dullness, uneven tone, and the appearance of fine lines.
AMP (adenosine monophosphate) is a naturally occurring molecule found throughout the body and plays an important role in cellular energy processes.
InnerSignal is suitable for all skin types, including dry, normal, combination, and mature skin. The formula is tested on sensitive skin as well.
Yes. The development of InnerSignal is supported by scientific research conducted by Otsuka and its research teams in Japan.
Your trial includes a 14-day supply of our AMP-powered serum, worth $45, free of charge (just pay for shipping). After the trial period, your subscription will continue and your card will be charged for the full amount unless canceled. We’ll email you before your trial ends, and you can cancel anytime during the trial period.
Your card won't be charged for the full-size product until your 14-day trial period ends. You can cancel any time before then, and we'll send you a reminder email a few days before your upcoming charge.
Subscribers receive automatic deliveries at their chosen frequency and can manage, pause, or cancel their subscription at any time.
Yes. You can cancel your subscription before your next billing date through your account portal.
No. The trial kit is yours to keep, even if you decide not to continue.
We offer free U.S. shipping on every subscription delivery. The 14-Day Trial Kit is subject to a separate shipping fee.
Currently, InnerSignal is available only within the United States.
Please contact hello@innersignal.us with your name and order number and we will be happy to help. Alternatively you can call us at 1-833-687-8628.
